The Midwest Region is one of ten United States regions that currently send teams to the Little League World Series, the largest youth baseball competition in the world. The region's participation in the LLWS dates back to 1957, when it was known as the Central Region. However, when the LLWS was expanded in 2001 from eight teams (four U.S. teams and four "International" teams from the rest of the world) to 16 teams (eight U.S. and eight International), the Central Region was split into the Midwest and Great Lakes Regions. Starting in 2022, 8 teams will be represented at the Midwest regional with the addition of Wisconsin. The U.S. states that are in Little League's Midwest Region:

Regional championship

Winner is indicated in green.

2001–2021

2022–present

Following the 2021 LLWS, Wisconsin has been moved from the Great Lakes Region to the Midwest Region. This move is a small part of a planned expansion of the LLWS from 16 to 20 teams. This expansion was originally scheduled to occur for 2021, but was delayed to 2022 due to the COVID-19 pandemic.

LLWS results

As of the 2024 Little League World Series.

Results by state

As of the 2024 Little League World Series.