The knockout phase of the 2009–10 UEFA Europa League began on 18 February, and concluded with the final at the Volksparkstadion in Hamburg, Germany on 12 May 2010. The knockout phase involved the 24 teams that finished in the top two in each group in the group stage and the eight teams that finished in third place in the UEFA Champions League group stage. All times are CET/CEST.

Format

Each tie in the knockout phase, apart from the final, was played over two legs, with each team playing one leg at home. The team that had the higher aggregate score over the two legs progressed to the next round. In the event that aggregate scores finished level, the team that scored more goals away from home over the two legs progressed. If away goals were also equal, 30 minutes of extra time were played. If goals were scored during extra time and the aggregate score was still level, the visiting team qualified by virtue of more away goals scored. If no goals were scored during extra time, there would be a penalty shootout after extra time. In the final, the tie was played over just one leg at a neutral venue. If scores were level at the end of normal time in the final, extra time would be played, followed by penalties if scores remained tied.

<section begin=Format /> The mechanism of the draws for each round was as follows:

Qualified teams

Teams advancing from group stage

Teams relegated from Champions League group stage

Bracket

Round of 32

<section begin=R32 /> The draw for the round of 32 took place on 18 December 2009. The first legs were played on 16 and 18 February, and the second legs were played on 23 and 25 February 2010. <section end=R32 />

First leg

Second leg

Benfica won 5–1 on aggregate. Anderlecht won 5–1 on aggregate. Marseille won 6–2 on aggregate. Panathinaikos won 6–4 on aggregate. Atlético Madrid won 3–2 on aggregate. Fulham won 3–2 on aggregate. Liverpool won 4–1 on aggregate. 3–3 on aggregate; Hamburger SV won on away goals. VfL Wolfsburg won 6–3 on aggregate. Standard Liège won 3–2 on aggregate. Werder Bremen won 4–2 on aggregate. Lille won 3–2 on aggregate. Sporting CP won 4–2 on aggregate. Juventus won 2–1 on aggregate. Valencia won 3–1 on aggregate. Rubin Kazan won 3–0 on aggregate.

Round of 16

<section begin=R16 /> The draw for the round of 16 took place on 18 December 2009, immidiately after the round of 32 draw. The first legs were played on 11 March, and the second legs were played on 18 March 2010. <section end=R16 />

First leg

Second leg

Fulham won 5–4 on aggregate. 5–5 on aggregate; Valencia won on away goals. Benfica won 3–2 on aggregate. Standard Liège won 4–1 on aggregate. Liverpool won 3–1 on aggregate. 2–2 on aggregate; Atlético Madrid won on away goals. Hamburger SV won 6–5 on aggregate. VfL Wolfsburg won 3–2 on aggregate.

Quarter-finals

<section begin=QF /> The draw for the quarter-finals was held on 19 March 2010. The first legs were played on 1 April, and the second legs were played on 8 April 2010. <section end=QF />

First leg

Second leg

Fulham won 3–1 on aggregate. Hamburger SV won 5–2 on aggregate. 2–2 on aggregate; Atlético Madrid won on away goals. Liverpool won 5–3 on aggregate.

Semi-finals

<section begin=SF /> The draw for the semi-finals was held on 19 March 2010, immediately after the quarter-final draw. The first legs were played on 22 April, and the second legs were played on 29 April 2010. <section end=SF />

First leg

Second leg

Fulham won 2–1 on aggregate. 2–2 on aggregate; Atlético Madrid won on away goals.

Final

<section begin=F /> The final took place on 12 May 2010 at the [Volksparkstadion](https://bliptext.com/articles/volksparkstadion) in [Hamburg](https://bliptext.com/articles/hamburg), Germany. A draw was held on 19 March 2010, after the quarter-final and semi-final draws, to determine the "home" team for administrative purposes. <section end=F />