The Yamaha YZ250F is a motocross motorcycle first released in 2001 by Yamaha. It features a DOHC, four-stroke engine and initially had a steel frame and subframe in 2001-2002. In 2003 it received an aluminum subframe, which was replaced in the 2006 model with an all-aluminum frame. The YZ250F has been praised for combining the broad-power characteristics of a four-stroke engine with the light handling more common in smaller, 125 cc two-stroke motorcycles. Despite the similar name to the YZ250, very few parts have been shared between the models through their history.

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