William Francis O'Donnell (died 4 February 1947) was an Irish politician who served for four years in Dáil Éireann. He was first elected to the Dáil as a Clann na Talmhan Teachta Dála (TD) for the Tipperary constituency at the 1943 general election. He was re-elected at the 1944 general election, but died in 1947. After his death, the by-election for his Dáil seat was won on 29 October 1947 by the Clann na Poblachta candidate, Patrick Kinane.