The Waynesboro Downtown Historic District is a national historic district in Waynesboro, Virginia. In 2002, it included 43 contributing buildings in the compact central business district of Waynesboro. The district includes churches, houses, mixed-use commercial buildings, banks, specialty stores, offices, a hotel, restaurants, and parking lots. Notable buildings include the First National Bank (1908–09), the LB&B Building (1929), and the General Wayne Hotel (1937-1938). It was listed on the National Register of Historic Places in 2002.