Vignole Borbera (Genoese: Vigneue) is a comune (municipality) in the Province of Alessandria in the Italian region of Piedmont, located about 100 km southeast of Turin and about 30 km southeast of Alessandria. As of 31 December 2004, it had a population of 2,154 and an area of 8.5 km2. The municipality of Vignole Borbera contains the frazioni (subdivisions, mainly villages and hamlets) Variano Inferiore, Variano Superiore and Precipiano. Vignole Borbera borders the following municipalities: Arquata Scrivia, Borghetto di Borbera, Grondona, Serravalle Scrivia, and Stazzano.