Contents
UPF1
Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog ) is a protein that in humans is encoded by the UPF1 gene.
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in both the cytoplasm and nucleus. When translation ends, it interacts with the functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
Interactions
UPF1 interacts with:
This article is derived from Wikipedia and licensed under CC BY-SA 4.0. View the original article.
Wikipedia® is a registered trademark of the
Wikimedia Foundation, Inc.
Bliptext is not
affiliated with or endorsed by Wikipedia or the
Wikimedia Foundation.