US Post Office-Owego is a historic post office building located at Owego in Tioga County, New York. It was designed in 1917 and built in 1919-1920 and is one of a number of post offices in New York State designed by the Office of the Supervising Architect under James A. Wetmore. It is a symmetrical one story, red brick clad building on a raised foundation executed in the Colonial Revival style. It is a contributing structure in the Owego Central Historic District. It was listed on the National Register of Historic Places in 1988.