Between 7 October 2001 and 30 August 2021, the United States lost a total of 2,459 military personnel in Afghanistan. Of this figure, 1,922 had been killed in action. An additional 20,769 were wounded in action. 18 operatives of the Central Intelligence Agency were also killed during the conflict. Further, there were 1,822 civilian contractor fatalities. The number of American fatalities reached 1,000 on February 19, 2010, when Reconnaissance Corporal Gregory Stultz of the U.S. Marines was killed by Taliban insurgents during the Battle of Marjah. By April 11, 2011, this figure stood at 1,515, and had surpassed 2,000 by September 2012. On August 6, 2011, the highest number of American fatalities in a single incident occurred in Wardak Province: 30 Americans (incl. 22 Navy SEALs), seven Afghan soldiers, and a civilian interpreter were all killed when their CH-47 Chinook was shot down; the attack was later claimed by the Taliban. On August 5, 2014, the highest-ranking American fatality occurred in Kabul: Major General Harold J. Greene of the United States Army was shot dead by 22-year-old Private Rafiqullah of the Afghan National Army; Rafiqullah had carried out the fragging after he was denied leave for Eid al-Fitr.

Numbers of fatalities

The United States Department of Defense lists 2,459 servicemembers as having died in Operation Enduring Freedom and Operation Freedom's Sentinel. Of these, 1,922 were due to hostile action and 534 non-hostile, and 3 status pending. Of those killed, 60 were confirmed to have died in Africa, Southeast Asia or Cuba in support of OEF – Horn of Africa, OEF – Philippines, OEF – Trans Sahara, and in the detainment of prisoners in Guantanamo Bay, Cuba. Five were killed due to hostile action. Thus, a total of 2,402 United States servicemen were killed in the war in Afghanistan. The website iCasualties.org lists 2,455 servicemembers and 10 CIA operatives as having died in Operation Enduring Freedom and Operation Freedom's Sentinel, including 49 who died in support of other OEF operations. This gives a total of 2,406 deaths of servicemen in support of operations in Afghanistan. The iCasualties.org figure of 2,406 is higher than the Department of Defense's officially stated figure, although according to the website all of the names listed at iCasualties.org have been confirmed by the Department of Defense. Many veterans have committed suicide as a result of psychological problems developed during their service.

Fatalities by month and year

All fatalities

Grand Total: 2,456 Source: Note: Table omits the deaths of six Department of Defense civilian employees killed in support of operations in Afghanistan and other countries.

Killed in action only

Grand Total: 1,928 Source: Note: Table omits the deaths of four Department of Defense civilian employees killed in action in support of operations in Afghanistan and other countries.

Publicized incidents of multiple deaths of U.S. service members in the war