Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction. The common cytokine-binding domain is related to the Fibronectin type III domain.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.

Examples

Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

Interleukin receptors

Colony stimulating factor receptors

Hormone receptor/neuropeptide receptor

Other