Tripoli Creek is a creek in the Unorganized North Part of Algoma District in northeastern Ontario, Canada. It is part of the Lake Superior drainage basin. The creek begins at West Tripoli Lake at an elevation of 424 m. It heads northeast under the Canadian Pacific Railway transcontinental mainline between the settlements of Amyot to the west and the Girdwood railroad flag stop, 1.6 km to the east, to reach Tripoli Lake. Tripoli Creek continues northeast, takes in the right tributary Ryerson Creek, and reaches its mouth at Esnagi Lake on the Magpie River at an elevation of 347 m.

Tributaries