This is a timeline of events in the history of the Cherokee Nation, from its earliest appearance in historical records to modern court cases in the United States. Some basic content about the removal of other southeastern tribes to lands west of the Mississippi River is included. In a series of treaties, these tribes ceded land to the United States.

1540–1775

1775–1811

1811–1829

1830s

1830–1832

1833–1835

1836–1837

1838

1839–1840

1841–present