Squinzano is a town and comune (municipality) in the province of Lecce in the Apulia region of south-east Italy. It is the twelfth-most populous city in the province of Lecce. Squinzano is also a specific area within the Apulian wine region. Squinzano DOC is produced in red and rosé versions, and is chiefly obtained from the Negroamaro grape, with a small addition of Malvasia Nera di Brindisi and Malvasia Nera di Lecce.