Sodium pertechnetate is the inorganic compound with the formula NaTcO4. This colorless salt contains the pertechnetate anion, that has slightly distorted tetrahedron symmetry both at 296 K and at 100 K while the coordination polyhedron of the sodium cation is different from typical for scheelite structure. The radioactive anion is an important radiopharmaceutical for diagnostic use. The advantages to 99Tc include its short half-life of 6 hours and the low radiation exposure to the patient, which allow a patient to be injected with activities of more than 30 millicuries. is a precursor to a variety of derivatives that are used to image different parts of the body.

Chemistry

is the starting material for most of the chemistry of technetium. Pertechnetate salts are usually colorless. is produced by oxidizing technetium with nitric acid or with hydrogen peroxide. The pertechnetate anion is similar to the permanganate anion but is a weaker oxidizing agent. It is tetrahedral and diamagnetic. The standard electrode potential for / is only +0.738 V in acidic solution, as compared to +1.695 V for /. Because of its diminished oxidizing power, is stable in alkaline solution. is more similar to. Depending on the reducing agent, can be converted to derivatives containing Tc(VI), Tc(V), and Tc(IV). In the absence of strong complexing ligands, is reduced to a +4 oxidation state via the formation of hydrate.

Pharmaceutical use

The half-life of 99Tc is long enough that labelling synthesis of the radiopharmaceutical and scintigraphic measurements can be performed without significant loss of radioactivity. The energy emitted from 99Tc is 140 keV, which allows for the study of deep body organs. Radiopharmaceuticals have no intended pharmacologic effect and are used in very low concentrations. Radiopharmaceuticals containing 99Tc are currently being applied in the determining morphology of organs, testing of organ function, and scintigraphic and emission tomographic imaging. The gamma radiation emitted by the radionuclide allows organs to be imaged in vivo tomographically. Currently, over 80% of radiopharmaceuticals used clinically are labelled with 99Tc. A majority of radiopharmaceuticals labelled with 99Tc are synthesized by the reduction of the pertechnetate ion in the presence of ligands chosen to confer organ specificity of the drug. The resulting 99Tc compound is then injected into the body and a "gamma camera" is focused on sections or planes in order to image the spatial distribution of the 99Tc.

Specific imaging applications

99Tc is used primarily in the study of the thyroid gland - its morphology, vascularity, and function. and iodide, due to their comparable charge/radius ratio, are similarly incorporated into the thyroid gland. The pertechnetate ion is not incorporated into the thyroglobulin. It is also used in the study of blood perfusion, regional accumulation, and cerebral lesions in the brain, as it accumulates primarily in the choroid plexus. Sodium pertechnetate cannot pass through the blood–brain barrier. In addition to the salivary and thyroid glands, localizes in the stomach. is renally eliminated for the first three days after being injected. After a scanning is performed, it is recommended that a patient drink large amounts of water in order to expedite elimination of the radionuclide. Other methods of administration include intraperitoneal, intramuscular, subcutaneous, as well as orally. The behavior of the ion is essentially the same, with small differences due to the difference in rate of absorption, regardless of the method of administration.

Other reactions involving the pertechnetate ion