The Second Presbyterian Church is a historic Presbyterian church located at 460 E. Main Street in Lexington, Kentucky. Construction began on the church in 1922, and it was dedicated in 1924; it was the third building used by its congregation, which was founded in the 1810s. Architects Cram & Ferguson designed the Gothic Revival church; Frankel & Curtis are also associated with the building. The church's main entrance features multiple gabled buttresses, a balcony under a large arched window, and a gable at its peak. On the west side of the church, a buttressed tower rises from the roof to a steep spire. The church was added to the National Register of Historic Places in 1980.