Second Old School Baptist Church of Roxbury is a historic Baptist church building on City Rd. 41 in Roxbury, Delaware County, New York. It is a 2-story, three-by-four-bay wood-frame building constructed in 1832–1833. The interior features a traditional meeting house plan. Also on the property is a small frame outhouse built about 1870, a three-step fieldstone carriage step, and cemetery. It was added to the National Register of Historic Places in 1999.