The Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role in a Motion Picture is an award presented annually by the Screen Actors Guild. It has been presented since the 1st Screen Actors Guild Awards in 1995 to a female actor who has delivered an outstanding performance in a leading role in a film released that year. The award has been presented 30 times, and 27 actresses have won the award. Jodie Foster was the award's first winner for Nell (1994). The most recent winner is Lily Gladstone who won for her performance in Killers of the Flower Moon (2023). Frances McDormand, Renée Zellweger, and Viola Davis have all won the award twice. Meryl Streep has the most nominations with ten.

Winners and nominees

1990s

2000s

2010s

2020s

Superlatives

Multiple winners

Multiple nominees

Note: Winners are indicated in bold type.