The Francis Bowes Sayre Sr. Highway or simply the Sayre Highway is a four-to-six lane, 192 km, primary national highway that connects Cagayan de Oro, Misamis Oriental to Kabacan, Cotabato. It traverses the provinces of Misamis Oriental, Bukidnon and Cotabato. The highway's name was Route 3 but was changed to Sayre Highway, in honor of Francis Bowes Sayre, Sr., the U.S. Philippine High Commissioner who spearheaded its construction. It extends southward through central Mindanao for a distance of about 161 km, linking the northern and southern arms of Route 1 (Digos–Butuan Highway). This section of the Philippine national highway was constructed during the American occupation of the Philippines. The parts of the highway are composed of National Route 10 (N10), a spur route of Asian Highway 26 in the north; and National Route 943 (N943) in the southern portion of the Philippine highway network.

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