Santa Margherita d'Adige was a comune (municipality) in the Province of Padua in the Italian region Veneto, located about 60 km southwest of Venice and about 35 km southwest of Padua. As of 31 December 2004, it had a population of 2,308 and an area of 12.7 km2. Santa Margherita d'Adige bordered the following former and current municipalities: Megliadino San Fidenzio (former), Megliadino San Vitale, Ospedaletto Euganeo, Piacenza d'Adige, Ponso, Saletto (former). Since 17 February 2018 Santa Margherita d'Adige is part of Borgo Veneto municipality.

Demographic evolution