Saint Luke's Health System is an Episcopal Church non-profit hospital network in the bi-state Kansas City metro area, located in northeast Kansas and northwest Missouri. With over 12,000 local employees, it is the third largest private employer in the Kansas City metro. Saint Luke's Health System traces its history to its flagship hospital, Saint Luke's Hospital of Kansas City, which was established in 1882. On January 1, 2024, its operations were merged with those of BJC HealthCare, forming BJC Health System.

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Cushing Hospital was closed in July 2020 because of financial difficulties caused by the COVID-19 pandemic in the United States.

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