Rock Creek is a 56 mi intermittent stream flowing in Lake and Harney counties in the U.S. state of Oregon. The source of Rock Creek is at an elevation of 6914 ft on Hart Mountain, while the mouth is at an elevation of 4557 ft in the Catlow Valley. Rock Creek has a 269 sqmi watershed. From its source northeast of Warner Peak, the creek flows generally northeast, with segments that flow generally north and others that flow generally east, across the Hart Mountain National Antelope Refuge. The creek flows through Hot Springs Campground, where Bond Creek, a named tributary, enters from the right. The creek passes by Antelope Hot Springs downstream of the campground. Further downstream, it flows through the refuge headquarters, where it passes under Frenchglen Road. The creek then runs roughly parallel to Poker Jim Ridge, on the left, before heading east into Rock Creek Reservoir and then into Catlow Valley. Catlow Valley is a closed basin, with no outlet to the sea.