In enzymology, a pyrroline-5-carboxylate reductase is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are L -proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-5-carboxylate, NADH, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ** L -proline:NAD(P)+ 5-oxidoreductase**. Other names in common use include proline oxidase, L -proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and ** L -proline-NAD(P)+ 5-oxidoreductase**. This enzyme participates in arginine and proline metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.

Human genes