Anhalt-Plötzkau was a principality located in Germany. It existed on two occasions. It was first established in 1544 following the partition of Anhalt-Dessau, but the principality ceased to exist following the death of Prince George III in 1553, at which point it was inherited by the prince of Anhalt-Zerbst. It was reestablished in 1603 with the partition of the unified principality of Anhalt; this time, in order to create a bigger principality, parts of Anhalt-Bernburg were extracted. This second incarnation lasted until 1665, at which point Prince Lebrecht succeeded as Prince of Anhalt-Köthen and Plötzkau returned to the principality of Anhalt-Bernburg.

Princes of Anhalt-Plötzkau (1544-1553)

To Anhalt-Zerbst 1553.

Princes of Anhalt-Plötzkau (1603-1665)

United with Anhalt-Bernburg 1665.