This is a list of winners and nominees of the Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series. The award is presented to the best performance by a lead actor in a television comedy series. Beginning with the 18th Primetime Emmy Awards, leading actors in comedy have competed alone. However, these comedic performances included actors from miniseries, telefilms, and guest performers competing against main cast competitors. Such instances are marked below: The 74th Primetime Emmy Awards are the first Emmys where there is no representation from any of the big four broadcast networks.

Winners and nominations

1950s

1960s

1970s

1980s

1990s

2000s

2010s

2020s

Programs with multiple awards

Performers with multiple wins

Programs with multiple nominations

Performers with multiple nominations

(*) refers to those who have won in this category

Superlatives

Total awards by network