This is a list of winners and nominees of the Primetime Emmy Award for Outstanding Guest Actress in a Comedy Series. Prior to 1989, the category was not gender-specific, and, thus, was called Outstanding Guest Performer in a Comedy Series. It is given in honor to an actress who has delivered an outstanding performance in a guest-starring role in a television comedy series. The current recipient is Jamie Lee Curtis for The Bear. Since the category change in 1989, a total of 34 actresses were awarded for their performances. The most awarded actress is Cloris Leachman, with 3 wins, followed by Tina Fey, Colleen Dewhurst, Kathryn Joosten, Jean Smart, Tracey Ullman, Betty White, and Maya Rudolph, with 2 wins. These awards, like the other "Guest" awards, were previously not presented at the Primetime Emmy Award ceremony, but, rather, at the Creative Arts Emmy Award ceremony.

Winners and nominations

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1970s

1980s

1990s

2000s

2010s

2020s

Performers with multiple wins

Programs with multiple awards

Performers with multiple nominations

Programs with multiple nominations