Polichnitos is a town and a former municipality on the island of Lesbos, North Aegean, Greece. Since the 2019 local government reform it is part of the municipality West Lesbos, of which it is a municipal unit. Population 3,438 (2021). The municipal unit is located in the central south coast of the island, adjacent to the south side of the Bay of Kalloni. It has a land area of 172.629 km2. Its municipal seat is in the town of Polichnítos. The next largest villages are Vrísa, Vasiliká, and Lisvóri.