Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil. It can be used to diagnose Horner's syndrome. In 2004, it remained marketed only in Germany.

Pharmacology

Pharmacodynamics

Pholedrine is described as a sympathomimetic, antihypotensive, and ephedrine-like agent.

Chemistry

Pholedrine, also known as 4-hydroxy-N-methylamphetamine, is a substituted phenethylamine and amphetamine derivative. It is structurally related to methamphetamine (N-methylamphetamine), norpholedrine (4-hydroxyamphetamine), oxilofrine (4,β-dihydroxy-N-methylamphetamine), and tyramine (4-hydroxyphenethylamine). It is used pharmaceutically as the sulfate salt. The predicted log P of pholedrine ranges from 1.12 to 1.7.

History

Pholedrine was synthesized by 1951.

Society and culture

Names

Pholedrine is the generic name of the drug and its INN, BAN, and DCF, while foledrina is its DCIT. The drug has been sold under brand names including Pholedrin Liquidum, Pholedrin-Longo-Isis, Presoitan, Veritain, and Veritol among others.

Other drugs

Pholedrine (4-hydroxymethamphetamine) is also a major metabolite of methamphetamine.