The Perené River is a Peruvian river on the eastern slopes of the South American Andes. It is formed at the confluence of the Chanchamayo and Paucartambo Rivers, 15 km above the community of Perené, actually two pueblos of Santa Ana and Pampa Silva divided by the river, at 650 m above sea level. The 165 km river flows in a south-easterly direction. The Perené joins the Ene River, 10 km below the community of Puerto Ocopa, at 400 m above sea level, and is called the Tambo River from then on.