Nebraska Highway 121 is a highway in northeastern Nebraska. It is a discontinuous highway with three segments:

Route description

Southern segment

The southern segment of Nebraska Highway 121 begins at an intersection with NE 32 west of Madison. It heads in a northward direction through farmland, passing through Battle Creek. Just north of Battle Creek, it intersects with US 275, where this segment terminates for about 15 mi.

Middle segment

The middle segment of Nebraska Highway 121 begins at NE 13 northwest of Pierce. It heads in a northward direction through farmland, where it intersects with US 20 in Osmond. NE 121 runs concurrently with US 20 for about 3.5 mi to the east, before splitting and continuing northward. It then intersects NE 59 before entering Wausa to the north. The highway turns to the east and then northward again as it passes through Wausa. Further north, it will meet NE 84 and the segment will terminate at that point, resuming about 10 mi to the northeast.

Northern segment

The third segment of Nebraska Highway 121 begins at NE 12 in Crofton. It heads northward from Crofton through farmland, passing by the Lewis and Clark State Recreation Area and Gavins Point Dam. At that point, the highway turns to the northeast and finally directly eastward. It meets with US 81 south of the South Dakota border and just a couple of miles south of Yankton. NE 121 terminates at US 81.

Major intersections