The Myx Music Awards for 2010 comprised nineteen categories of "favorite" and two special awards.

Nomination night

Nomination night took place in February, 2010 at Eastwood Central Plaza, Quezon City, with a number of hosts and performances. With six nominations each, Gloc-9 (Favorite Music Video, Favorite Male Artist, Favorite Urban Video, Favorite Collaboration, Favorite Remake, Favorite MYX Live! Performance), Rico Blanco (Favorite Music Video, Favorite Song, Favorite Artist, Favorite Male Artist, Favorite Rock Video, Favorite MYX Live! Performance) and Chicosci (Favorite Music Video, Favorite Song, Favorite Artist, Favorite Group, Favorite Rock Video, Favorite MYX Celebrity VJ) got the most number of nominations.

Nominees and winners

Winners are in bold text.

Favorite Music Video

Favorite Song

Favorite Artist

Favorite Female Artist

Favorite Male Artist

Favorite Group

Favorite Mellow Video

Favorite Rock Video

Favorite Urban Video

Favorite New Artist

Favorite Indie Artist

Favorite Collaboration

Favorite Remake

Favorite Media Soundtrack

Favorite Guest Appearance in a Music Video

Favorite MYX Celebrity VJ

Favorite MYX Live! Performance

Favorite MYX Bandarito Performance

Favorite International Video

Special awards

Special Citation

Myx Magna Award