Muhammad Ayub Khuhro (14 August 1901 – 1980) was a Pakistani politician who served as the Chief Minister of Sindh for three terms, and as the Defence Minister in the Feroz Khan Noon Ministry. In 1946, Khuhro was elected by the Sindh Provincial Assembly to be among the three members to represent the province in the Constituent Assembly of India but he abdicated attendance until the Mountbatten Plan sanctioned the creation of Pakistan and its own constituent assembly. Hamida Khuhro, an academic, is his daughter and has written his biography.