The MTV Europe Music Award for the best UK & Ireland act has been a regional category since 1998 and have been won by 18 different acts The last Irish winners to win in this category was Westlife in 2000. Before 2024, when Hozier became one of the nominees, the Irish band The Thrills, which received a nomination in 2003, were the last Irish nominees in the category. British boy band One Direction, which includes an Irish member, Niall Horan, won the Awards in 2012, 2013, and 2014. British girl group Little Mix is currently the most awarded and nominated act and female group in this category, winning a of total six times out of seven nominations. The following is a list of the MTV Europe Music Award winners and nominees for Best UK & Ireland Act.

Winners and nominees

Winners are listed first and highlighted in bold.

1990s

2000s

2010s

2020s

Performers with multiple awards

Performers with multiple nominations