Monesiglio is a comune (municipality) in the Province of Cuneo in the Italian region Piedmont, located about 70 km southeast of Turin and about 45 km east of Cuneo. Monesiglio borders the following municipalities: Camerana, Gottasecca, Mombarcaro, and Prunetto. It is home to a castle, built in the 13th century, later (17th century) rebuilt into a late-Gothic palace. It houses several 16th-century frescoes.