The Midtown Historic District is a historic district in the city of Mobile, Alabama, United States. It was placed on the National Register of Historic Places on November 29, 2001, with a small boundary increase on November 18, 2020 It is roughly bounded by Taylor Avenue, Government Street, Houston Street, Kenneth Street, Springhill Avenue, and Florida Street. The district covers 467 acre and contains 1,270 contributing buildings. The majority of the contributing buildings range in age from the 1880s to the 1950s and cover a wide variety of architectural styles. The district was significantly affected by a tornado on December 25, 2012.

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