Middleton Railway station served the town of Middleton. The station opened on 5 January 1857 when the Lancashire and Yorkshire Railway (L&YR) opened a branch line to serve the town from Middleton Junction. The station was located to the south east of the junction of Oldham Road (now the A669) and Townley Street. Originally the station had a single platform. It was rebuilt with two platforms in 1885-1886. There were goods lines on both sides of the main running lines and a goods shed to the south. The goods yard was able to accommodate most types of goods including live stock and was equipped with a five ton crane. A Cotton shed (described on the map as a goods shed) opened about 1907, it had a rail link into Neva Cotton Mills. The station closed to passengers on 7 September 1964 and completely on 11 October 1965 when the branch also closed.