Michael Karas (born 1952) is a German physical chemistry scientist and Professor, known for his researches on matrix-assisted laser desorption/ionization (MALDI), a technique in mass spectrometry. Michael Karas studied Chemistry at the University of Bonn, where he obtained a PhD in the field of physical chemistry in 1982. From 1983 to 1986, he was part of the Hillenkamp research group in the Institut für Biophysik at Goethe University Frankfurt. In 1987, he followed Hillenkamp at Münster and both formed a group in the Faculty of Medicine at University of Münster. He returned to Frankfurt in 1995 as a full professor for Instrumental Analytical Chemistry.

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