Mezzomerico is a comune (municipality) in the Province of Novara in the Italian region Piedmont, located about 90 km northeast of Turin and about 20 km north of Novara. Mezzomerico borders the following municipalities: Agrate Conturbia, Divignano, Marano Ticino, Oleggio, Suno, and Vaprio d'Agogna. The name of the town shows its origins as Celtic Mediomatrici settlement; the name was attested as Mediomadrigo in 980.