The use of medicinal clay in folk medicine goes back to prehistoric times. Indigenous peoples around the world still use clay widely, which is related to geophagy. The first recorded use of medicinal clay goes back to ancient Mesopotamia. A wide variety of clays are used for medicinal purposes—primarily for external applications, such as the clay baths in health spas (mud therapy). Among the clays most commonly used are kaolin and the smectite clays such as bentonite, montmorillonite, and Fuller's earth. However, their use is declining, and modern evidence-based medicine has ended the use of many types.

History

Ancient Egypt and Mesopotamia

The first recorded use of medicinal clay is on Mesopotamian clay tablets around 2500 BC. Also, ancient Egyptians used clay. The Pharaohs’ physicians used the material as anti-inflammatory agents and antiseptics. It was used as a preservative for making mummies and is also reported that Cleopatra used clays to preserve her complexion. The Ebers Papyrus of about 1550 BC (but containing the tradition going back many centuries earlier) is an important medical text from ancient Egypt. It describes the use of ochre for a wide variety of ailments, including for intestinal problems.

Classical times

Lemnian clay

This was a clay used in Classical Antiquity. It was mined on the island of Lemnos. Its use continued until the 19th century, as it was still listed in an important pharmacopoeia in 1848 (the deposits may have been exhausted by then). Pliny reports about the Lemnian earth: "if rubbed under the eyes, it moderates pain and watering from the same, and prevents the flow from the lachrymal ducts. In cases of haemorrhage it should be administered with vinegar. It is used against complaints of the spleen and kidneys, copious menstruation, also against poisons, and wounds caused by serpents." Lemnian clay was shaped into tablets, or little cakes, and then distinctive seals were stamped into them, giving rise to its name terra sigillata—Latin for 'sealed earth'. Dioscorides also commented upon the use of terra sigillata. Another physician famous in antiquity, Galen, recorded numerous cases of the internal and external uses of this clay in his treatise on clay therapy. "Galen... used as one of his means for curing injuries, festering wounds, and inflammations terra sigillata, a medicinal red clay compressed into round cakes and stamped with the image of the goddess Diana. This clay, which came from the island of Lemnos, was known throughout the classical world." Clay was prescribed by the Roman obstetrician, gynecologist, and pediatrician Soranus of Ephesus, who practiced medicine around 100–140 AD.

Other clays used in classical times

The other types of clay that were famous in antiquity were as follows. All the above seem to have been bentonitic clays.

Medieval times

In medieval Persia, Avicenna (980–1037 CE), the 'Prince of Doctors', wrote about clay therapy in his numerous treatises. Ibn al-Baitar (1197–1248), a Muslim scholar born at Malaga, Spain, and author of a famous work on pharmacology, discusses eight kinds of medicinal earth. The eight kinds are:

Renaissance period

A French naturalist Pierre Belon (1517–1564) was interested in investigating the mystery of the Lemnian clay. In 1543, he visited Constantinople where, after making enquiries, he encountered 18 types of different products marketed as Lemnian Earth (he was concerned about possible counterfeits). He then made a special journey to Lemnos, where he continued his investigation, and tried to find the source of the clay. He discovered that it was extracted only once a year (on 6 August) under the supervision of Christian monks and Turkish officials. In 1588 the English ethnographer and translator Thomas Harriot wrote in A Briefe and True Report of the New Found Land of Virginia that Algonquians of the mid–Atlantic region of North America treated various sores and wounds with wapeih, "very like to terra sigillata" that English surgeons and physicians found to be of the same kind "of vertue and more effectuall" than the contemporary European sort.

Preparation of clay

Clay gathered from its original source deposit is refined and processed in various ways by manufacturers. This can include heating or baking the clay, since the raw clay tends to contain a variety of microorganisms. Too much processing, likewise, may reduce the clay's therapeutic potential. In particular, Mascolo et al. studied 'pharmaceutical grade clay' versus 'the natural and the commercial herbalist clay', and found an appreciable depletion of trace elements in the pharmaceutical grade clay. On the other hand, certain clays are typically heated or cooked before use. Medicinal clay is typically available in health food stores as a dry powder, or in jars in its liquid hydrated state – which is convenient for internal use. For external use, the clay may be added to the bath, or prepared in wet packs or poultices for application to specific parts of the body. Often, warm packs are prepared; the heat opens up the pores of the skin, and helps the interaction of the clay with the body. In the European health spas, the clay is prepared for use in a multitude of ways – depending on the traditions of a particular spa; typically it is mixed with peat and matured in special pools for a few months or even up to two years. "The majority of spas … use artificial ponds where the natural ("virgin") clay is mixed with mineral, thermo-mineral, or sea water that issues in the vicinity of the spas or inside the spa buildings."

Trace minerals

Clays contain large amounts of trace minerals. It is common to see as many as 75 different trace minerals in Montmorillonite clays. Specific trace minerals that various clays possess vary very widely. Also, the amount of any particular trace mineral in any specific clay varies a lot among clays from different locations. For example, the amount of iron in various bentonite clays can vary from 2.5 to 3%.

Uses

Skin conditions

Many types of skin conditions have been treated by the application of medicinal clay. Montmorillonite has shown its effectiveness in this area. It has also been used as a base ingredient for tissue engineering. Clay is used in many dermatological over-the-counter remedies, such as in acne treatments (this information may not be mentioned on the label specifically).

Internal use

There are many over-the-counter remedies for internal (oral) use that contained clay before discontinuation. Examples included Kaopectate (Upjohn), Rheaban (Leeming Div., Pfizer), and Diar-Aid (Thompson Medical Co.). The labels on all of these showed the active ingredient to be Attapulgite, each tablet containing 600 (or 750 mg) of this component along with inert materials or adjuvants. However, since April 2003, attapulgite medication was discontinued due to lack of evidence according to the U.S. Food and Drug Administration. Kaolin was also used to treat cholera around the start of the 20th century. An early proponent was German physician Julius Stumpf.

Heavy metal chelation

It has been used as a scientifically unsupported chelation treatment for heart disease and autism.

Aflatoxicosis

Bentonite has the ability to reduce the adverse effects of aflatoxicosis.

Side effects of ingestion

Substances discontinued such as kaolin and attapulgite were formerly considered gastric demulcents and diarrhea medication, until official studies by the USFDA disproved these views. Clays are classified as excipients and their main side-effects are that of neutral excipients, which is to impair and slow down absorption of antibiotics, hormones and heart medication amongst others by coating the digestive tract and this slowed down absorption can lead to increased toxicity of some medication (e.g. citrate salts) which can become toxic if not metabolized quickly enough, which is one contraindication of attapulgite. Usual mild side-effects are nausea, slowed down absorption of nutrients from food (in excess dosage of medicinal clay) and constipation. It has been found that prolonged exposure to bentonite in humans can actually have harmful effects.

Common medicinal clays