Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.

Pharmacology

In vitro study shows that maslinic acid inhibits serine proteases, key enzymes necessary for the spread of HIV within an individual's body. It also has in vitro antiproliferative effects on colon cancer cells. Maslinic acid increases EAAT2 (GLT-1) glutamate reuptake and may reduce glutamatergic toxicity in rats. Additionally, maslinic acid serves as a glycogen phosphorylase inhibitor in mouse liver, as evidenced by increased glycogen accumulation in rainbow trout liver.

Clinical significance

Maslinic acid demonstrates antioxidant capabilities against oxygen and nitrogen reactive species. It also exhibits a suppressive impact on proinflammatory cytokines like TNF-α and IL-6 in murine macrophages. These mechanisms could contribute to enhanced protein synthesis, growth rates, and joint support. Maslinic acid has been shown to improve muscle mass in the elderly when combined with resistance exercise.