Mao Fumei (, 9 November 1882 – 12 December 1939) was the first wife of Chiang Kai-shek, and the biological mother of Chiang Ching-Kuo. Mao was born in Fenghua, Ningbo, Zhejiang Province, and, like most women of the era, she was illiterate. She married Chiang Kai-shek in an arranged marriage in 1901. When Chiang came back from Japan, he divorced her in 1921. She was killed in 1939 in a Japanese air raid on the Former residence of Chiang Kai-shek in Xikou.