Malesco is a comune (municipality) in the Province of Verbano-Cusio-Ossola in the Italian region Piedmont, located about 130 km northeast of Turin and about 20 km north of Verbania, the provincial capital. As of 31 December 2004, it had a population of 1,478 and an area of 43.2 km2. Malesco is the most populous comune in Val Vigezzo and has a station on the Domodossola–Locarno railway which runs along the valley. The neighbouring municipalities are: Cossogno, Craveggia, Re, Santa Maria Maggiore, Trontano, Valle Cannobina, Villette.

Demographic evolution