Main Street Historic District is a national historic district located at Roxbury in Delaware County, New York. The district contains 86 contributing buildings, three contributing sites, three contributing structures, and one contributing object. The southern end of the district is dominated by the Gothic Revival style Jay Gould Memorial Reformed Church (1892), the Roxbury Central School (1939), and the Kirkside estate. Located nearby is a Greek Revival style Methodist church erected in 1858. Financier Jay Gould was raised nearby and in the 1890s began an interest in the development of Roxbury. It was listed on the National Register of Historic Places in 1988.

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