Lygosominae is the largest subfamily of skinks in the family Scincidae. The subfamily can be divided into a number of genus groups. If the rarely used taxonomic rank of infrafamily is employed, the genus groups would be designated as such, but such a move would require a formal description according to the ICZN standards.

Genera

Several Lygosominae genera were notorious "wastebin taxa" in the past, with scientists assigning more or less closely related species to them in a haphazard fashion and without verifying that the new species were close relatives of the genera's type species. What was once placed in Lygosoma, for example, is now divided among some 15 genera, not all in this subfamily. Similarly, Mabuya and Sphenomorphus are having species moved elsewhere.

Now placed elsewhere

Incertae sedis and obsolete genera