Tennessee was admitted to the Union on June 1, 1796. Its United States Senate seats were declared vacant in March 1862 owing to its secession from the Union. They were again filled from July 1866. Tennessee's current senators are Republicans Marsha Blackburn and Bill Hagerty. Kenneth McKellar was Tennessee's longest-serving senator (1917–1953).

List of senators

! rowspan=3 | 1 ! rowspan=2 | 1 ! 2 ! rowspan=3 | 2 ! 3 ! rowspan=14 | 4 ! rowspan=4 | 3 ! rowspan=3 | 4 ! rowspan=2 | 5 ! rowspan=2 | 6 ! rowspan=2 | 7 ! rowspan=2 | 5 ! rowspan=7 | 8 ! rowspan=10 | 6 ! rowspan=2 | 9 ! rowspan=13 | 10 ! rowspan=5 | 7 ! 8 ! rowspan=3 | 9 ! rowspan=3 | 11 ! rowspan=2 | 10 ! 11 ! rowspan=2 | 12 ! rowspan=4 | 12 ! rowspan=7 | 13 ! rowspan=3 | 13 ! rowspan=3 | 14 ! 14 ! rowspan=2 | 15 ! rowspan=3 | 15 ! rowspan=3 | 16 ! rowspan=6 | 16 ! 17 ! 18 ! rowspan=3 | 19 ! rowspan=13 | 17 ! rowspan=3 | 20 ! 21 ! rowspan=12 | 22 ! rowspan=2 | 18 ! rowspan=5 | 19 ! rowspan=3 | 23 ! rowspan=3 | 20 ! rowspan=6 | 24 ! 21 ! 22 ! rowspan=6 | 23 ! rowspan=23 | 25 ! rowspan=3 | 24 ! 25 ! 26 ! rowspan=3 | 27 ! 28 ! rowspan=6 | 29 ! rowspan=8 | 30 ! rowspan=12 | 26 ! 31 ! rowspan=2 | 32 ! rowspan=9 | 33 ! rowspan=3 | 27 ! rowspan=11 | 28 ! rowspan=4 | 34 ! rowspan=2 | 35 ! rowspan=5 | 36 ! rowspan=6 | 29 ! rowspan=9 | 37 ! rowspan=6 | 30 ! rowspan=5 | 31 ! rowspan=3 | 38