This is a list of top-division association football clubs in CAF countries. CAF, the African football confederation, includes all African countries as members. The French Overseas Department of Réunion and the autonomous island of Zanzibar have their own football associations which are associate members of CAF (but not members of FIFA). Mayotte, a French Overseas Territory, Saint Helena, a British Overseas Territory, and Western Sahara, a disputed territory, are not members of CAF or any other football confederation. Each of the CAF member countries have their own football league systems. The clubs playing in each top-level league compete for the title as the country's club champions, and also for places in next season's CAF club competitions, i.e., the CAF Champions League and the CAF Confederation Cup. Due to promotion and relegation, the clubs playing in the top-level league in many countries are different every season. The champions of the previous season in each country are listed in bold.

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Algeria

As of 2023–24 season:

Angola

As of 2022–23 season:

Benin

As of 2013–14 season:

Botswana

As of 2023-24 season:

Burkina Faso

As of 2021-22 season:

Burundi

As of 2023–24 season

Cameroon

As of 2013-14 season

Cape Verde

As of 2013-2014 season

Group A

Group B

Central African Republic

As of 2013 season (2013 season was to have started end of February but was cancelled due to military crisis):

Chad

As of 2013 season:

Comoros

As of 2013 season

Congo

As of 2013 season

Democratic Republic of the Congo

As of 2013–2014 season

Djibouti

As of 2023-24 season

Egypt

As of 2017–18

Equatorial Guinea

As of 2014 season

Región Continental

Región Insular

Eritrea

Eswatini

As of 2013-14 season

Ethiopia

As of 2013 season

Gabon

As of 2014 season

Gambia

As of 2014 season

Ghana

As of 2013-14 season

Guinea

As of 2014 season

Guinea-Bissau

As of 2014 season

Ivory Coast

As of 2013 season

Kenya

As of 2023-24 season

Lesotho

As of 2013-14 season

Liberia

As of 2013-14 season

Libya

As of 2013-14 season

Madagascar

As of 2013-14season, (LIGUE DES CHAMPIONS)

Group A

Group B

Malawi

As of 2024 season

Mali

As of 2013 season

Mauritania

As of 2013-14 season

Mauritius

As of 2023-24 season

Morocco

As of 2022-23 season

Mozambique

As of 2024 season

Namibia

As of 2020/2021 season

Niger

As of 2014 season:

Nigeria

As of 2014:

Réunion

As of 2013 season:

Rwanda

As of 2023-24 season

São Tomé and Príncipe

As of 2013-14 season

Senegal

As of 2013-14 season

Seychelles

Season 2023-24

Sierra Leone

As 2013

Somalia

As of 2013-14 season:

South Africa

As of 2024–25 season:

South Sudan

As of 2013

Sudan

As of 2014 season

Tanzania

Togo

As of 2014 season

Tunisia

As of 2023-24 season

Uganda

As of 2023-24 season

Zambia

As of 2023-24 season

Zanzibar

As of 2023-24 season

Zimbabwe

As of 2024 season: