The following is a list of notable people who were born, or have lived a significant portion of their lives, in the Lehigh Valley region of eastern Pennsylvania.

Authors, journalists, playwrights, and poets

Business and politics

Film, television, and stage

Music

Religion

Science

Sports

Collegiate sports

Major League Baseball (MLB)

National Basketball Association (NBA)

National Football League (NFL)

Olympic athletes

Professional boxing

Professional golf

Professional racing

Professional soccer

Professional tennis

World Wrestling Entertainment (WWE)

Other sports

Visual arts

Others