This is a list of North American animals extinct in the Holocene that covers extinctions from the Holocene epoch, a geologic epoch that began about 11,650 years before present (about 9700 BCE) and continues to the present day. Recently extinct animals in the West Indies and Hawaii are in their own respective lists. Many extinction dates are unknown due to a lack of relevant information.

Mammals (class Mammalia)

Armadillos, pampatheres, and glyptodonts (order Cingulata)

Chlamyphorid armadillos and glyptodonts (family Chlamyphoridae)

Anteaters and sloths (order Pilosa)

Megalonychid ground sloths (family Megalonychidae)

Mylodonts (family Mylodontidae)

Nothrotheriid ground sloths (family Nothrotheriidae)

Elephant-like mammals (order Proboscidea)

Gomphotheres (family Gomphotheriidae)

Mastodons (family Mammutidae)

Elephants and mammoths (family Elephantidae)

Sea cows (order Sirenia)

Dugongs (family Dugongidae)

Lagomorphs (order Lagomorpha)

Pikas (family Ochotonidae)

Rodents (order Rodentia)

Beavers (family Castoridae)

Hamsters, voles, lemmings, muskrats, and New World rats and mice (family Cricetidae)

Possibly extinct

Gophers (family Geomyidae)

Carnivorans (order Carnivora)

Cats (family Felidae)

Locally extinct

Dogs (family Canidae)

Extinct in the wild

Bears (family Ursidae)

Locally extinct

Earless seals (family Phocidae)

Martens, polecats, otters, badgers, and weasels (family Mustelidae)

Extinct in the wild

Odd-toed ungulates (order Perissodactyla)

Horses and allies (family Equidae)

Locally extinct

Even-toed ungulates (order Artiodactyla)

Camels and llamas (family Camelidae)

Peccaries (family Tayassuidae)

Gray whales (family Eschrichtiidae)

Locally extinct

True deer (family Cervidae)

Locally extinct

Cattle, goats, antelopes, and others (family Bovidae)

Locally extinct

Birds (class Aves)

Landfowl (order Galliformes)

Pheasants and allies (family Phasianidae)

Waterfowl (order Anseriformes)

Ducks, geese, and swans (family Anatidae)

Grebes (order Podicipediformes)

Grebes (family Podicipedidae)

Swifts, treeswifts, and hummingbirds (order Apodiformes)

Hummingbirds (family Trochillidae)

Possibly extinct

Pigeons and doves (order Columbiformes)

Pigeons and doves (family Columbidae)

Extinct in the wild

Rails and cranes (order Gruiformes)

Rails (family Rallidae)

Possibly extinct

Cranes (family Gruidae)

Shorebirds (order Charadriiformes)

Plovers, dotterels, and lapwings (family Charadriidae)

Sandpipers (family Scolopacidae)

Possibly extinct

Auks (family Alcidae)

Albatrosses and petrels (order Procellariiformes)

Northern storm petrels (family Hydrobatidae)

Possibly extinct

Storks and allies (order Ciconiiformes)

Storks (family Ciconiidae)

New World vultures (order Cathartiformes)

New World vultures and condors (family Cathartidae)

Extinct in the wild

Teratorns (family Teratornithidae)

Hawks and relatives (order Accipitriformes)

Hawks, eagles, kites, harriers and Old World vultures (family Accipitridae)

Owls (order Strigiformes)

True owls (family Strigidae)

Falcons (order Falconiformes)

Falcons and caracaras (family Falconidae)

Woodpeckers and allies (order Piciformes)

Woodpeckers (family Picidae)

Possibly extinct

Parrots (order Psittaciformes)

Holotropical parrots (family Psittacidae)

Perching birds (order Passeriformes)

True finches (family Fringillidae)

Thrashers, mockingbirds, tremblers, and New World catbirds (family Mimidae)

Possibly extinct

New World blackbirds (family Icteridae)

New World sparrows (family Passerellidae)

Wrens (family Troglodytidae)

New World warblers (family Parulidae)

Possibly extinct

Reptiles (class Reptilia)

Turtles and tortoises (order Testudines)

Mud and musk turtles (family Kinosternidae)

Tortoises (family Testudinidae)

Amphibians (class Amphibia)

Frogs (order Anura)

True toads (family Bufonidae)

Extinct in the wild

Freshbelly frogs (family Craugastoridae)

Possibly extinct

Poison dart frogs (family Dendrobatidae)

Tree frogs and allies (family Hylidae)

Possibly extinct

Salamanders (order Urodela)

Lungless salamanders (family Plethodontidae)

Ray-finned fish (class Actinopterygii)

Minnows and allies (order Cypriniformes)

Suckers (family Catostomidae)

Carps and minnows (family Cyprinidae)

Extinct in the wild

Catfishes (order Siluriformes)

Ictalurids (family Ictaluridae)

Salmon, trout and relatives (order Salmoniformes)

Salmon, trout and relatives (family Salmonidae)

Possibly extinct

Silversides (order Atheriniformes)

Neotropical silversides (family Atherinopsidae)

Possibly extinct

Toothcarps (order Cyprinodontiformes)

Pupfishes (family Cyprinodontidae)

Possibly extinct

Extinct in the wild

Topminnows and North American killifishes (family Fundulidae)

Splitfins (family Goodeidae)

Extinct in the wild

Poeciliids (family Poeciliidae)

Possibly extinct

Extinct in the wild

Lionfishes and sculpins (order Scorpaeniformes)

Cottids (family Cottidae)

Sticklebacks (family Gasterosteidae)

Perchs and allies (order Perciformes)

Perchs (family Percidae)

Malacostracans (class Malacostraca)

Isopods (order Isopoda)

Marine pillbugs (family Sphaeromatidae)

Extinct in the wild

Decapods (order Decapoda)

Family Atyidae

Family Astacidae

Family Cambaridae

Possibly extinct

Amphipods (order Amphipoda)

Whale lice (family Cyamidae)

Insects (class Insecta)

Mayflies (order Ephemeroptera)

Spiny-headed burrowing mayflies (family Palingeniidae)

Family Acanthametropodidae

Stoneflies (order Plecoptera)

Green stoneflies (family Chloroperlidae)

Grasshoppers, crickets, and katydids (order Orthoptera)

Short-horned grasshoppers (family Acrididae)

Katydids (family Tettigoniidae)

Book lice, bark lice, and sucking lice (order Psocodea)

Chicken body lice (family Menoponidae)

Possibly extinct

Bird chewing lice (family Philopteridae)

Possibly extinct

Mammal lice (family Trichodectidae)

Possibly extinct

Beetles (order Coleoptera)

True weevils (family Curculionidae)

Butterflies and moths (order Lepidoptera)

Pygmy moths and midget moths (family Nepticulidae)

Trumpet leaf-miner moths (family Tischeriidae)

Shiny head-standing moths (family Argyresthiidae)

Gossamer-winged butterflies (family Lycaenidae)

Grass moths (family Crambidae)

Caddisflies (order Trichoptera)

Long-horned caddisflies (family Leptoceridae)

Family Rhyacophilidae

Arachnids (class Arachnida)

Order Mesostigmata

Family Halarachnidae

Order Sarcoptiformes

Family Analgidae

Family Psoroptoididae

Family Pterolichidae

Family Pteronyssidae

Family Xolalgidae

Snails and slugs (class Gastropoda)

Mud snails (family Hydrobiidae)

Family Lithoglyphidae

Family Lottiidae

Bladder snails (family Physidae)

Ramshorn snails (family Planorbidae)

Pleurocerids (family Pleuroceridae)

Bivalves (class Bivalvia)

Order Unionida

Family Unionidae

Roundworms (phylum Nematoda)

Order Rhabditida

Family Onchocercidae

Family Strongyloididae