This is a detailed list of human spaceflights from 1961 to 1970, spanning the Soviet Vostok and Voskhod programs, the start of the Soviet Soyuz program, the American Mercury and Gemini programs, and the first lunar landings of the American Apollo program.

Flights between 50 miles and 100 kilometers

In addition to the above spaceflights, eleven flights of the North American X-15 reached a maximum altitude above 50 miles but below 100 kilometers, thus satisfying the U.S. definition of spaceflight but failing to surpass the Kármán line. Among the twelve X-15 pilots, only Neil Armstrong and Joe Engle would travel to space following their participation in the program. Eleven of the thirteen flights above 50 miles were made in the X-15-3, the program's third plane; only two were made in the X-15-1, its first. In the below table, "spaceflight" and related phrases refer to the American convention.