This is a list of crossovers in video games. "Crossovers" occur when otherwise usually separated fictional elements - video game characters, settings, and gameplay mechanics - exist and interact in the same video game.

First and second-party crossovers

This list includes crossovers and cameos of characters from video games owned by one company and close affiliates.

Third-party crossovers

This list includes video games that have crossovers from two or more separate companies.

Comic book/video game crossovers

Video games that have comic book franchise characters encountering or facing off against other comic book franchise characters or third-party video game characters in a crossover video game or as a guest character in a third-party video game include:

Cartoon/video game crossovers

Video games that have cartoon franchise characters encountering or facing off against other cartoon franchise characters or video game characters in a crossover video game or as a guest character in a third-party video game include:

Manga/anime crossovers

Video games that have manga franchise characters or anime franchise characters encountering or facing off against other manga or anime franchise characters in a crossover video game include: