This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. ''Chemical/generic names are listed first, with brand names in parentheses. All drugs listed are approved specifically for major depressive disorder unless noted otherwise.''

Selective serotonin reuptake inhibitors (SSRIs)

Selective serotonin reuptake inhibitors include:

Discontinued/withdrawn

Serotonin–norepinephrine reuptake inhibitors (SNRIs)

Serotonin–norepinephrine reuptake inhibitors include:

Serotonin–dopamine reuptake inhibitor (SDRIs)

Serotonin–dopamine reuptake inhibitors include: None currently marketed

Discontinued/withdrawn

Serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRIs)

Serotonin–norepinephrine–dopamine reuptake inhibitors include:

Serotonin modulators and stimulators (SMSs)

Serotonin modulators and stimulators include:

Serotonin antagonist and reuptake inhibitors (SARIs)

Serotonin antagonist and reuptake inhibitors include:

Discontinued/withdrawn

Norepinephrine reuptake inhibitors (NRIs)

Norepinephrine reuptake inhibitors include:

Off-label only

Norepinephrine–dopamine reuptake inhibitors (NDRIs)

Norepinephrine–dopamine reuptake inhibitors include:

Off-label only

Discontinued/withdrawn

Tricyclic antidepressants (TCAs)

Tricyclic antidepressants include: Opipramol (Insidon), tianeptine (Stablon, Coaxil) and amineptine (discontinued; formerly Survector, Maneon) are chemically TCAs but are pharmacodynamically atypical, and are therefore grouped elsewhere.

Discontinued/withdrawn

Tetracyclic antidepressants (TeCAs)

Tetracyclic antidepressants include: Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs).

Monoamine oxidase inhibitors (MAOIs)

Monoamine oxidase inhibitors include

Irreversible

Non-selective

Discontinued/withdrawn

Selective for MAO-B

Reversible

Non-selective

Discontinued/withdrawn

Selective for MAO-A

These drugs are sometimes described as reversible inhibitors of MAO-A (RIMAs). Discontinued/withdrawn

Mixed

Non-selective

Atypical antipsychotics

Atypical antipsychotics include:

Others

Marketed

Off-label only

Discontinued/withdrawn

Over-the-counter

The following antidepressants are available both with a prescription and over-the-counter:

Adjunctive treatments

Atypical antipsychotics

Atypical antipsychotics include:

Off-label only

Typical antipsychotics

Typical antipsychotics include: None currently approved

Off-label only

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Dopamine reuptake inhibitor

Dopamine reuptake inhibitors include: None currently approved

Off-label only

Others

Off-label only

Combination products